MIK665 CAS No.: 1799631-75-6
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The date of payment from buyers deliver within days
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Jiangsu
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Validity to:
Long-term effective
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Last update:
2023-06-29 12:58
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Browse the number:
462
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Jiangsu
Address:Weitang Town, Suzhou Yantang Industrial Zone, P.R.China, 215000
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Chemical Structure: MIK665
CAS No.: 1799631-75-6
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MIK665(MIK 665, S 64315, S64315)
Catalog No.: URK-V595Â Â Only Used For Lab.
MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
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Biological ActivityMIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1.
Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
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Physicochemical Properties
M.Wt |
875.413 |
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Formula |
C47H44ClFN6O6S |
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CAS No. |
1799631-75-6 |
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Storage |
Solide Powder -20 °C 3years; 4°C 2years |
In Solvent -80°C 6 Months -20°C 1 Months |
Solubility |
10 mM in DMSO |
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Chemical Name |
(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid |
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References
1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.
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Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use
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